Indian University Technology Database

Life Sciences

Biochemical diagnostic tool for early detection of cancer/mass screening diagnostic potentialline
Ref No:KCRC01/002
Sub Class: Pharmaceuticals and Healthcare
Technology Outcome: Process
Development Status: Preliminary Research
IPR Status: Not Patented
Technology Description: In this preliminary study a negative correlation was found between poly-ADP-ribosylation of blood lymphocyte proteins mice during initiation of carcinogenesis induced by a hepatocarcinogen, dimethylnitrosamine (DMN) in a low dose chronic exposure condition. Slot- and Western blot immunoassay has been employed to measure total cellular poly-ADP-ribosylation of lymphocyte proteins and that of individual lymphocyte proteins respectively. Results show significant lowering of total PAR of lymphocyte proteins within 2 weeks of DMN treatment as revealed by slot blot immunoassay. By Western blot analysis it has been found that two lymphocyte proteins seemed to be the main causes for this observation. The preliminary report brings forward the possibility of using immunoassay of poly-ADP-ribosylation of blood lymphocytes as a possible predictive assay of initiation of carcinogenesis. The application area is Medical diagnosis. The competitive advantage are: (i)The assay is non-radioactive & sensitive (ii) It is inexpensive and easy to apply.
Technology owner: Private individual and R & D institute
Suggested transfer means: Know How
Type of technology partner sought:
Geographical areas where partners are sought: Asia & Pacific
Source: North Eastern Hill University